Isobornyl methacrylate (IBOMA) was synthesized by microwave irradiation using camphene and methacrylic acid as raw materials. The reaction conditions were optimized by Design Expert 8.0, based on the single factor experiments of the reaction time, microwave temperature, microwave power, molar ratio of camphene and methacrylic acid and catalyst dose. These variables were optimized by Central Composite experimental design in combination with response surface analysis . The results showed that the optimal conditions were as follows : reaction temperature 43℃ , n(camphene)/n(Methacrylic acid)=1:0.8 , catalyst dose 10% , irradiation time 25min and microwave power 400W . Under the optimal conditions,the esterification rate can reach 82.23% .