Magnetic metal organic skeleton materials have the characteristics of ability to increase drug targeting. Based on the previous experiments, Fe3O4@ZIF-8 was prepared by hydrothermal method using FeCl3?6H2O, sodium acetate, Zn（NO3)2?6H2O and 2-methylimidazole as the main raw materials. Magnetic metal organic skeleton material. The materials were characterized . The material was used as the drug carrier and the loaded drug tetracycline was used as the main evaluation index and detected by UV spectrophotometer. The results showed that the saturated loading reached 12.296mg / g under the conditions of pH = 9, material dosage 5mg and drug concentration 30mg / L.