Abstract: The trifluoropropyl vinyl silicone oil (FVSA) was prepared by ring-opening reaction from 1,3,5-tris(3,3,3-trifluoropropyl)methylcyclotrisiloxane(D3F), tetramethylcyclotetrasiloxane (D4vi) and hexamethyldisiloxane(MM). Alkoxy modified fluorinated polysiloxane (FVT) was prepared by hydrosilylation addition with trimethoxysilane (TMS) and (FVSA).The nano-modified fluorosilicone resin (FVT-SiO2) was obtained via fractional hydrolysis and polycondensation with FVT, tetraethyl orthosilicate (TEOS) and 1H,1H,2H,2H-perfluorooctyltrimethoxysilane (POTS). The transparent anti-fingerprint coating was prepared with FVT-SiO2 as a film forming material. The structure, morphology and performance of the products were characterized by FTIR, AFM and SEM, and the influence of reaction conditions of fractional hydrolysis on the contact angle of coating was discussed. The results showed that: after FVT and TEOS were reacted in 2h, the POTS was added to the further fractional reactions, and the spherical FVT-SiO2 were obtained which dispersed homogeneously with diameter approximately 150nm. Moreover, when the mass concentration of treating solution of FVT-SiO2 was 2wt% and the number of layers was 3, the coating showed optimal transparency, adhesion , hydrophobicity and oleophobicity. The water and oil contact angles reached 138.5°and 109°, respectively.