The preparation technology of a pre-dispersed C.I. Pigment Yellow 14 with hydrophobic properties was studied. Polyethylene wax was added to the aqueous dispersion while the coupling reaction was finished. The effects of mass ratio, heating temperature, heating time, stirring speed, pH value and particle size of polyethylene wax were investigated．A pre-dispersed C.I. Pigment Yellow 14 which has a diameter of 1-2mm, uniform size and a nuclear-shell structure was prepared under optimal conditions: mass ratio of 1:1, heating time of 20min at 80℃, 40-60 mesh polyethylene wax, pH=7, stirring speed of 250r/min. The pre-dispersed pigment is easy to separate from the water phase. The water content decreases from 79.29% to 59.85%. The filtration time is shortened by twenty times. The FPV is reduced from 0.75MPa/g to 0.06MPa/g, and the dispersion is greatly improved. The obtained pigments do not need to be crushed by high shear force and result in the reduction of the dust and energy. The preparation method meets the application requirements and reduces the cost. The present technology has a great benefit for environmental protection and is easy to industrialize.