文章摘要
张光杰,杜磊,路志芳,袁超.不同环糊精对角鲨烯的包合作用[J].精细化工,2019,36(4):
不同环糊精对角鲨烯的包合作用
Clathration of Squalene with Different Cyclodextrins
投稿时间:2018-08-24  修订日期:2018-12-06
DOI:
中文关键词: 相溶解度  环糊精  角鲨烯  包合作用
英文关键词: phase solubility  cyclodextrins  squalene  clathration
基金项目:国家自然科学基金项目(面上项目,重点项目,重大项目);河南省科技攻关项目
作者单位E-mail
张光杰 安阳工学院 65671385@qq.com 
杜磊 安阳工学院  
路志芳 安阳工学院  
袁超 齐鲁工业大学  
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中文摘要:
      角鲨烯是一种含有6个非共轭双键的直链三萜,其生理功能显著,但因其水溶性及稳定性较差使其应用受限。采用相溶解度法,在温度为25℃、40℃和55℃的条件下,研究α-环糊精、β-环糊精、γ-环糊精、羟丙基-β-环糊精及甲基-β-环糊精对角鲨烯的包合作用,绘制相溶解图并计算包合过程中的热力学参数。结果表明,各相溶解图均为AL型,且γ-环糊精的包合效果及增溶效果最为显著。γ-环糊精对角鲨烯的包合常数K最大可达1778.0860 L/mol,最大可将角鲨烯的溶解度增大至原来的309.0935倍。包合过程中的热力学参数焓变(ΔH)及熵变(ΔS)均为正值,而吉布斯自由能(ΔG)均为负值,表明包合过程为吸热的自发反应,且无序化增加(熵增加)是环糊精空腔包封角鲨烯分子的主要驱动力。
英文摘要:
      Squalene is a linear triterpenoid with six non-conjugated double bonds. Its physiological function is remarkable, but its application is limited due to its poor water solubility and stability. The clathration of squalene with alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin, hydroxypropyl-beta-cyclodextrin and methyl-beta-cyclodextrin were studied by phase solubility method at temperatures of 25℃, 40℃ and 55℃. While the phase dissolution diagrams were plotted and the thermodynamic parameters during the inclusion process were calculated. The results showed that all the phase dissolving diagrams were AL type, and the inclusion effect and solubilization effect of gamma-cyclodextrin were the most significant. The inclusion constant K of gamma-cyclodextrin for squalene was up to 1778.0860 L/mol, and the solubility of squalene was increased to 309.0935 times. The thermodynamic parameters enthalpy change (ΔH) and entropy change (ΔS) of the inclusion process are both positive values, while the Gibbs free energy (ΔG) are both negative values, indicated that the inclusion process is an endothermic spontaneous reaction, and the increase of disorder (entropy increase) is the main driving force for the encapsulation of squalene molecules in cyclodextrin cavities.
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