The organic fluorochemical has an extensive application in the field of fine chemicals due to the unique physical properties. However, there are some problems existed in the traditional fluorination process. There is no doubt that, as a new technology of high efficiency mass and heat transfer, microreaction technology is expected to solve some of the problems. Therefore, according to the types of fluorinated substrate, the main progress made in the field of microreaction technology in recent twenty years, and the application of microreaction technology in fluorination is reviewed. The application of microreaction technology can greatly improve the of efficiency fluorination and it is believed that the emergence of microreaction technology will promote the development of fluorination reaction towards a more efficient, safe, environmentally friendly, controllable and continuous direction. Neverthless, it is necessary to break through the traditional thinking mode and further study on the application of microreaction technology in continuous post-processing.