文章摘要
马艺函.一种谷胱甘肽-富勒烯光敏剂的合成及其光动力效果研究[J].精细化工,2019,36(4):
一种谷胱甘肽-富勒烯光敏剂的合成及其光动力效果研究
Synthesis and Photodynamic Study of Glutathione Modified Fullerenene
投稿时间:2019-01-04  修订日期:2019-01-17
DOI:
中文关键词: 富勒烯  还原性谷胱甘肽  光敏剂  光动力治疗
英文关键词: fullerene  reduced glutathione  photosentizer  photodynamic therapy
基金项目:国家自然科学基金项目(面上项目,重点项目,重大项目)
作者单位E-mail
马艺函 中南民族大学 mayihan@iccas.ac.cn 
摘要点击次数: 113
全文下载次数: 0
中文摘要:
      设计合成安全高效的光敏剂对于光动力肿瘤治疗具有重要意义。本文将还原性谷胱甘肽通过亲核加成反应键合至C60上合成了一种水溶性富勒烯光敏剂(C60-OH-GSH),并对其结构组成进行了表征确认。C60-OH-GSH在水溶液中形成尺寸均一的纳米颗粒,并且能够稳定存在于多种生理溶液中,具有优异的生物相容性。在1 umol/L的低浓度下,C60-OH-GSH就能够被光激发诱导产生大量的活性氧,从而引起多种肿瘤细胞损伤凋亡;同时在避光条件下,50 umol/L的C60-OH-GSH对正常细胞没有损伤。C60-OH-GSH作为一种安全高效的光敏剂,有望应用于肿瘤的光动力治疗。
英文摘要:
      It is important to design and synthesize safe and effective photosensitizers in photodynamic therapy for tumors. In this paper, a water-soluble fullerene photosensitizer (C60-OH-GSH) was synthesized by bonding reduced glutathione to fullerene C60 via nucleophilic addition reaction, and its chemical composition and structure were confirmed. C60-OH-GSH aggregates to nanoparticles of uniform size in aqueous solution, and it gives high stability in multiple physiological solutions, indicating its excellent biocompatibility. Under irradiation, C60-OH-GSH at low concentration of 1 ?mol/L can generate sufficient reactive oxygen species to induce cellular damage and apoptosis of various tumor cells, while in the dark it exhibit non negative effect on normal cells even at concentrations up to 50 ?mol/L, which makes it a promising photosensitizer for phototherapeutic application.
  查看/发表评论  下载PDF阅读器
关闭