文章摘要
孟祥俭,陈南春,王秀丽,郭小炜,李玉妍,解庆林.二甲酸钾微胶囊的构建与缓释抑菌性[J].精细化工,2019,36(11):
二甲酸钾微胶囊的构建与缓释抑菌性
Construction and sustained release bacteriostasis of potassium diformate microcapsules
投稿时间:2019-04-28  修订日期:2019-06-12
DOI:
中文关键词: 沸石分子筛  二甲酸钾  海藻酸钠  壳聚糖  微胶囊  缓释
英文关键词: zeolite  potassium diformate  sodium alginate  chitosan  microcapsules  sustained release
基金项目:国家自然科学基金项目(面上项目,重点项目,重大项目)
作者单位E-mail
孟祥俭 桂林理工大学 1249844819@qq.com 
陈南春 桂林理工大学 cnc@glut.edu.cn 
王秀丽 桂林理工大学  
郭小炜 桂林理工大学  
李玉妍 桂林理工大学  
解庆林 桂林理工大学  
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中文摘要:
      以自制沸石分子筛为载体,通过水热法将二甲酸钾负载形成芯材,海藻酸钠、壳聚糖为壳材料,以复凝聚法制备出缓释微胶囊。通过FT-IR、XPS进行结构表征,缓释及抑菌率测试进行性能表征。结果表明:沸石分子筛与二甲酸钾之间可形成复配效应,构成微胶囊的芯材;壳聚糖和海藻酸钠发生静电作用,形成聚电解质膜,构成微胶囊的壳材料;制备的微胶囊模拟在pH=2.0的胃环境中稳定,在pH=7.2的肠道环境中二甲酸钾得到释放,并在3 h内可释放完全;微胶囊包封率为68.33%,微胶囊中二甲酸钾的释放量为137.50 mg/g。微胶囊对大肠杆菌的生长具有一定的抑制作用,并随着微胶囊浓度的增大对大肠杆菌的抑制率呈现增长的趋势,最高抑菌率可以达到85%。
英文摘要:
      The core material was prepared through the self-made zeolite loaded potassium diformate (KDF) by hydrothermal method, the sodium alginate (SA) and chitosan (CS) were used as shell material, then the sustained-release microcapsules were prepared between core material and shell material by a complex coac-ervation method. The structure was characterized by FT-IR and XPS, the performance was characterized by sustained release and inhibition rate experiment. The results show that a compounding effect can be formed between the zeolite and the KDF to form a core material of the microcapsules, CS and SA form a polyelectrolyte membrane through electrostatic interaction, which constitutes the shell material of the microcapsules. The microcapsules were stable in the simulated stomach environment with pH=2.0, KDF of microcapsules were released in the intestinal environment of pH=7.2 and can be completely released within 3 h. The entrapment efficiency was 68.33%, the release amount of KDF in microcapsules were 137.50 mg/g. The prepared microcapsules have an inhibitory effect on the growth of E. coli, and the inhibition rate with E. coli increases with the increase of the concentration of microcapsules and the highest inhibition rate can reach 85%.
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