A red blood cell membrane bionic nano-drug loading system (Au-Cur@RBC) was designed and developed to improve the shortcomings of curcumin, such as poor stability in water, poor absorption and fast metabolism, etc. The anticancer drug curcumin is loaded on the surface of small-sized gold nanoparticles that are favorable for encapsulation through hydrophobic interaction, and then the drug-loaded nanoparticles are encapsulated in erythrocyte membrane vesicles by physical extrusion. The results show that the prepared gold nanoparticles have high uniformity, good dispersibility, and an average particle size of 13.18 nm. The encapsulation rate of curcumin in curcumin nanoparticles is 86.85%, and the drug loading rate is 20.25%. The loading of gold nano-particles can significantly improve the stability of curcumin, and gold-curcumin nanoparticles still retain 52% of curcumin after being stored in an aqueous solution for 30 days. At the same time, the results of dark field mi-croscopy show that the coating of red blood cells has improved the ability of Au-Cur@RBC prepared to refract and diffract the incident light of the dark field microscope, thereby presenting a clearer image. The above results indicate that the prepared bionic nanoparticles show potential for application in cancer treatment and imaging.