文章摘要
星点设计-效应面法优化右旋布洛芬/酸改性蒙脱土干混悬剂的制备工艺
Optimization of Preparation of S( )-ibuprofen/Acid-Montmorillonite Dry Suspension by Composite Design-response Surface Method
投稿时间:2017-05-15  修订日期:2018-01-26
DOI:
中文关键词: 星点设计  效应面法  右旋布洛芬  酸化蒙脱土
英文关键词: central composite design, response surface method, S( )-ibuprofen, acid-montmorillonite
基金项目:
作者单位E-mail
李婷婷 山西医科大学 lily8631@163.com 
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中文摘要:
      通过星点设计-效应面法优化右旋布洛芬/酸改性蒙脱土(S( )-IBU/acid-MMT)干混悬剂的制备工艺。以蒙脱土的比表面积和孔容为考察指标,采用3因素5水平星点设计考察盐酸浓度、反应时间、反应温度对干混悬剂制备工艺的影响,并对结果进行二元多项式线性回归方程拟合,经效应面法预测最佳处方;借助现代分析技术对干混悬剂进行结构表征。右旋布洛芬/酸改性蒙脱土干混悬剂最佳条件为:盐酸浓度3.3 mol/L,反应时间5.5 h,温度55 ℃,酸改性的MMT比表面积达318.8 m2/g,孔容0.51 cm3/g,载药量最高可达460.8 mg/g。星点设计-效应面法适用于右旋布洛芬/酸改性蒙脱土干混悬剂制备工艺优化,以此方法建立的数学模型具有良好的预测性,所得干混悬剂具有更高的载药量。
英文摘要:
      To optimize the formulation of S( )-IBU/acid-MMT dry suspension by the central composites design-response surface methodology. Using surface area and pore volume as indexes, the influence of hydrochloric acid concentration; reaction time and temperture was investigated by central composite design-response surface method. The results were fitted by second-order polynomial equation, and the optimal preparation technology was predicted according to formulation. The quality of S( )-IBU/acid-MMT composites were characterizedby powder XRD and SEM. Central composite design finalized prescription is 3.3 mol/L, 5.5 h, 55 ℃, its BET surface area and pore volume is 318 m2/g, 0.51 cm3/g, respectively.The acid-MMT loading capacity 460.8 mg/g. Using the central composite design-response surface method to optimize the preparation of S( )-IBU/acid-MMT dry suspension has a good prediction S( )-IBU/acid-MMT dry suspension showsmore capacity by central composites design.
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