文章摘要
抗癫痫1,2,4-三氮唑类衍生物研究进展
Progress in 1,2,4-Triazole Derivatives with Antiepileptic Activity
投稿时间:2018-06-27  修订日期:2018-11-26
DOI:
中文关键词: 1,2,4-三氮唑  抗惊厥活性  神经毒性
英文关键词: 1,2,4-triazole  anticonvulsant activity  neurotoxicity
基金项目:天然药物活性物质及与功能国家重点实验室开放课题资助项目(GTZK201805);山东省高校科技计划项目资助项目(J16LC13).
作者单位E-mail
耿延汝 青岛科技大学化工学院 1274415571@qq.com 
丁静 青岛科技大学化工学院  
黄龙江 青岛科技大学化工学院 huanglj@qust.edu.cn 
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中文摘要:
      根据含1,2,4-三氮唑结构单元化合物的结构特点,分并环类和非并环类总结了其抗癫痫活性方面的研究进展,重点分析了不同结构类型与其抗癫痫活性以及神经毒性之间的关系。得出结论:1,2,4-三氮唑并喹啉及喹唑啉衍生物和三氮唑硫酮衍生物因具有良好的活性、较低的毒性从而具有进一步研究和开发价值;在此基础上,对1,2,4-三氮唑类化合物抗癫痫活性未来的研究方向进行了展望。
英文摘要:
      According to the structural characteristics of compounds containing 1,2, 4-triazole moiety, the research progress on antiepileptic activities of fused heterocyclic and non-fused heterocyclic compounds is summarized. The relationship between different structural types with antiepileptic activities and neurotoxicity is emphatically analyzed. It is concluded that 1,2,4-triazole fused quinoline derivatives, quinazoline derivatives and triazole thione derivatives are valuable for further research and development due to their good activity and low toxicity. Finally, the future research directions of 1,2,4-triazole derivatives with antiepileptic activity are prospected.
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