文章摘要
载甲钴胺香蕉纤维素微晶/PLGA介孔材料的制备及性能研究
Preparation and Properties of banana microcrystalline cellulose/ PLGA mesoporous materials loading mecobalamin
投稿时间:2018-07-31  修订日期:2018-11-05
DOI:
中文关键词: 香蕉纤维素微晶  甲钴胺  介孔材料  载体  缓释
英文关键词: banana microcrystalline cellulose  mecobalamin  mesoporous composite  carrier  controlled release
基金项目:广西有色金属及特色材料加工重点实验室开放基金(GXYSOF1802);广西天然高分子化学与物理重点实验室培育基地开放基金(2018ZYB07);广西区级大学生创新创业训练计划项目(201810603140)
作者单位E-mail
庞锦英 化学与材料科学学院 pangjinying@126.com 
黄春艳 广西师范学院化学与材料科学学院  
蓝春波 广西师范学院化学与材料科学学院  
谭登峰 广西师范学院化学与材料科学学院  
莫羡忠 广西师范学院化学与材料科学学院  
刘钰馨 广西师范学院化学与材料科学学院  
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中文摘要:
      从香蕉树皮中提取香蕉纤维素微晶,将甲钴胺、香蕉纤维素微晶和乳酸-羟基乙酸共聚物(PLGA)制备成载甲钴胺香蕉纤维素微晶/PLGA介孔材料。运用SEM、比表面积及孔径分析仪(BET)、热重-质谱联用仪(TG-MS)和FTIR对产物进行了表征;采用紫外分光光度计对载甲钴胺介孔材料进行了载药率、包封率、体外释放度测定。红外谱图分析表明,所制备的香蕉纤维素微晶的主要成分为纤维素;BET法测定结果表明,载甲钴胺香蕉纤维素微晶/PLGA介孔材料的平均孔直径[4V(孔体积)/A(表面积)]为17.89nm;TG-MS结果表明,载甲钴胺香蕉纤维素微晶/PLGA介孔材料分解温度约为300℃;体外释放实验表明,该材料对甲钴胺有较好的控释作用,药物释放遵循零级释放动力学方程。
英文摘要:
      The banana microcrystalline cellulose was prepared by the banana fiber, and the esoporous materials were prepared by the mecobalamin, banana microcrystalline cellulose and PLGA. The esoporous materi-als were characterized by SEM, specific surface area and pore size analysis (BET), Thermogravimetric mass spectrometry (TG-MS) and FT-IR. The drug load content, encapsulation efficiency, and in vitro re-lease rate of mesoporous materials loading mecobalamin were studied by the UV spectrophotometry. FT-IR spectrum analysis showed that the main component of microcrystalline cellulose was cellulose. The BET results showed that the average pore diameter [4V(pore volume)/A(surface area)] of banana micro-crystalline cellulose/PLGA mesoporous materials loading mecobalamin was 17.89nm. TG-MS results showed that the decomposition temperature of the materials were about 300℃. The results indicated that the materials had great control release ability, the drug release following zero-order release kinetics.
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