文章摘要
尼卡巴嗪的合成工艺改进
Improved Synthesis of Nicarbazin
投稿时间:2019-02-19  修订日期:2019-05-05
DOI:
中文关键词: 尼卡巴嗪  抗球虫药  4,4’-二硝基二苯基脲  2-羟基-4,6-二甲基嘧啶  合成
英文关键词: nicarbazin  coccidiostat  4,4’-Dinitrocarbanilide  2-hydroxy-4,6-dimethylpyrimidine  synthesis
基金项目:
作者单位E-mail
徐金雷 1.中牧实业股份有限公司
2.湖北中牧安达药业有限公司 
215082611@qq.com 
摘要点击次数: 55
全文下载次数: 0
中文摘要:
      以对硝基苯胺和三光气为原料,合成了4,4’-二硝基二苯基脲(DNC),副产物氯化氢气体用冷甲醇吸收,产生的溶液用于合成2-羟基-4,6-二甲基嘧啶(HDP)。以尿素和乙酰丙酮为原料,在氯化氢甲醇溶液中合成了HDP。以DNC和HDP的甲醇溶液反应合成了抗球虫药尼卡巴嗪,并用1H NMR对其结构进行了表征。对溶剂、反应温度和投料比等影响反应的因素进行了优化。结果表明,以二甲苯为溶剂,n(对硝基苯胺): n(三光气) =6:1时,在130℃下反应15h,DNC的收率可达94%;以氯化氢甲醇为溶剂,n(乙酰丙酮): n(尿素) =1.0:1.1,回流下反应5h,HDP的收率为93%以上;以甲醇为溶剂,n(DNC) : n(HDP)=1.0:1.1,室温反应5h,尼卡巴嗪的总收率可达93%。同时通过并联反应,缩短了生产周期,提高了产品质量的稳定性。
英文摘要:
      4,4’-Dinitrocarbanilide(DNC) was synthesized by 4-nitroaniline and triphosgene. The by-product hydrogen chloride gas was absorbed by cold methanol. It produced HCI-methanol solution which can be used for synthesizing 2-hydroxy-4,6-dimethylpyrimidine(HDP). The HDP was synthesized in the HCl-methanol as solvent with urea and acetylacetone as raw materials. Coccidiostat nicarbazin was synthesized through the reaction of DNC and the solution of HDP in methanol. Its structure was characterized by 1H NMR. The factors that influenced the reaction such as solvent, reaction temperature and feed ratio etc were optimized. The result shows, when the 4-nitroaniline to triphoshene ratio was 6:1 in xylene as solvent, reaction temperature was 130℃ and reaction time was 15h, the yield of DNC was 94%; when the acetylacetone to urea ratio was 1.0:1.1 in the HCl-methanol as solvent, reflux reaction time was 5h, the yield of HDP was above 93%; when the DNC to HDP ratio was 1.0:1.1 in methanol as solvent, the reaction was through 5h under room temperature, the total yield of Nicarbarzin could reach to 93%. Meanwhile, the production cycle was shortened and the stability of product quality was improved through parallel reactions.
View Fulltext   查看/发表评论  下载PDF阅读器
关闭