文章摘要
多巴胺-β-环糊精/α-生育酚的分子识别及包结物性能
Molecular recognition of dopamine-β-cyclodextrin derivative/α-tocopherol and performance of inclusion complex
投稿时间:2020-02-07  修订日期:2020-03-05
DOI:
中文关键词: 多巴胺-β-环糊精  α-生育酚  主客体包合  包封率  可控释放  抗氧化
英文关键词: dopamine-β-cyclodextrin  α-tocopherol  host-guest inclusion complex  encapsulation efficiency  controllable release  antioxidant
基金项目:中央高校基本科研基金
作者单位E-mail
张冬梅 江南大学 zdm228@163.com 
杨成 江南大学 cyang@jiangnan.edu.cn 
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中文摘要:
      为了提升α-生育酚(α-TOC)在环境中的稳定性,增强其包封率及药物有效利用,以多巴胺(DA)改性的β-环糊精(β-CD-6-DA)为包结物主体分子对α-TOC进行主-客体分子识别,得到稳定的包结复合物β-CD-6-DA/α-TOC。采用UV-vis、2D-NOESY与连续变量Job’s法探究了β-CD-6-DA的疏水空腔对α-TOC的包封率、分子识别行为及主客体包结比。结果表明,改性后的β-CD-6-DA对α-TOC的包封率高达99.3%±0.7%,促进了α-TOC进入疏水空腔中的深度,并将包结物的包结比由2 : 1提升至1 : 1。此外,对β-CD-6-DA/α-TOC包结物的生物性能进行探讨,发现其展现出良好的细胞相容性,35 ℃的药物响应性可控释放及协同增强的抗氧化清除活性。
英文摘要:
      In order to improve the stability of α-tocopherol (α-TOC) under natural environment and enhance its encapsulation rate and drug utilization, β-cyclodextrin derivative (β-CD-6-DA) modified by dopamine was used as host molecule to self-embed α-TOC, thereby obtaining stable inclusion complex (β-CD-6-DA/α-TOC). The encapsulation rate, molecular recognition behaviors and inclusion proportion of β-CD-6-DA on α-TOC were investigated using UV-vis, 2D-NOESY, and continuous variable Job’s methods, which exhibited up to 99.3±0.7% of encapsulation efficiency, promoted embedded depth of α-TOC inside hydrophobic cavity, and increased inclusion proportion from 2 : 1 to 1 : 1. Furthermore, the biological properties of β-CD-6-DA/α-TOC inclusion complex were discussed, revealing excellent cytocompatibility, controlled release at 35 ℃, and enhanced anti-oxidative scavenging capacity.
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