The whole ginger rod-based adhesive was prepared with ginger stalk as raw material. Firstly, through the pretreatment of guaiacol under acidic conditions, the in-situ phenolic modification of lignin was realized while the main components of ginger stem were separated, so that a large number of phenolic hydroxyl groups were grafted into the molecular structure of lignin, which greatly improved the chemical reactivity of lignin. The whole ginger rod-based adhesive was prepared without solid-liquid separation using the residual solid of pretreated cellulose and the extract of degraded lignin and hemicellulose products as raw materials, and compared with the ginger rod lignin-based adhesive prepared by the extract after solid-liquid separation to remove the cellulose solid. Studies have shown that both adhesives have shown good performance indicators. It can be seen from TG that the whole ginger rod-based adhesive exhibits better thermal stability. The whole straw-based particleboard was prepared by using the above two adhesives. The effects of the two adhesives on the properties of wood-based panels were investigated by testing the static bending strength ( MOR ), internal bonding strength ( IB ) and thickness swelling rate ( 24h TS ) of particleboard. Compared with the particleboard prepared by the ginger stalk lignin adhesive, the particleboard prepared by the whole ginger stalk-based adhesive showed higher static bending strength (21.26 MPa) and internal bonding strength ( 0.42 MPa > 0.40 MPa ), and lower water absorption expansion rate (16.74 %). The whole ginger rod-based adhesive prepared in this study has a simple process and realizes the full component utilization of straw.