Asymmetric synthesis of R-glabridin
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    Abstract:

    R-Glabridin is one of the unique isoflavones in glycyrrhiza glabra, which has a broad spectrum of biological activities. In this study, R-glabridin has been obtained via seven steps from 7-hydroxychromen-4-one by protection of phenolic hydroxyl groups, esterification of enol, Heck asymmetric coupling, deprotection, cyclization, reduction and demethylation and so on, the total yield was 23.5% and the ee value of the final product was 98.9%. The structures of products were confirmed by 1HNMR and MS. This method has the advantage of mild reaction conditions, easy operation and high yield.

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History
  • Received:August 29,2020
  • Revised:October 07,2020
  • Adopted:October 12,2020
  • Online: March 01,2021
  • Published: