文章摘要
陈婉毓,陈葵.海藻酸钠/脲醛树脂复合微胶囊的缓释动力学特性[J].精细化工,2019,36(11):
海藻酸钠/脲醛树脂复合微胶囊的缓释动力学特性
Slow-release Dynamics of Composite Microcapsules of Sodium Alginate/Urea-formaldehyde Resin
投稿时间:2019-03-18  修订日期:2019-04-23
DOI:
中文关键词: 海藻酸钠  脲醛树脂  核壳结构  缓控释  动力学
英文关键词: sodium alginate  urea-formaldehyde resin  core-shell structure  slow/controlled release  dynamics
基金项目:上海市科委项目
作者单位E-mail
陈婉毓 华东理工大学 1098302015@qq.com 
陈葵 华东理工大学 chenkui@ecust.edu.cn 
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中文摘要:
      采用两步法制备海藻酸钠/脲醛树脂复合微胶囊。在树脂化阶段引入海藻酸钠(SA)参与脲醛树脂(UF)的缩聚反应形成复合壳层,制备得到复合微胶囊。通过FTIR、TG、SEM、粒度分析等表征微胶囊的结构特征、组成成分、表观形貌、粒度分布,结果表明:SA的引入可有效改善脲醛树脂微胶囊的团聚现象,提高药物的包覆率至60%以上。释放性能研究显示复合微胶囊的缓释能力较脲醛树脂微胶囊提高,72d累计释放率由27.5%增至44.5%,且释放速率受pH、温度的影响,25℃下酸性介质中t50为27天。释放行为均可用Korsmeyer-Pappas动力学模型进行描述。
英文摘要:
      Composite microcapsules of sodium alginate/urea-formaldehyde resin were prepared in two steps. Then sodium alginate(SA) was added to the condensation polymerization of urea-formaldehyde resin(UF) , forming composite shells at the second step. FTIR, TG, SEM and granulometer were used to characterize the structure, composition, morphology and size distribution of microcapsules. The results showed that the agglomeration could be effectively improved and the encapsulation efficiency was increased to more than 60%. In addition, the composite microcapsules have higher release ability than UF microcapsules as the cumulative release was increased from 27.5% to 44.5% within 72 days. Moreover, the drug release behavior of modified microcapsules exhibit some pH and temperature dependence. More than 50% of the avermectin added was released within 27 days in acidic medium at 25℃. The release behavior generally followed the Korsmeyer-Pappas dynamic model.
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