Page 240 - 《精细化工》2023年第4期

g926g ㇫㏳ࡃጒ FINE CHEMICALS す 40 ࢤ

ͧ⌨ߍݯȠ2 mL V(Ά㙵)ńV(Ⅱ)=1ń1 ⮱⌤व⋟ͧ 㶕 4 Ꮒ➖᠀ᆂ
⏣ݯ喑ბ⍖̸ࣺᏁȡ Table 4 Substrate scope
2.2 Ꮒ➖᠀ᆂ
ౕᰭхࣺᏁ᲎У̸喑ᄦࣺᏁ⮱ᮛ䔯ᕔ䔈㵹γⵁ
⾣喑㐀᳉݄λ㶕 3ȡ⩞㶕 3 जⴒ喑㠜⩟䛈㟠⣜̷ः
ࣺᏁ 喍ϔ➖喎
Аധ⮱⩢䉌ᕔᄦϔ➖ϔ⢴ᰶ䒰᭫㦄⮱ᒞ৺喑㟠⣜̷ Ꮌत ĕ Ĕ
ᬣ䬡/h ϔ⢴/%
ᰶ॥⩢ၽധఏᬣ喑ϔ➖ϔ⢴䒰ສ喍Ꮌत 5~8喎ȡ㠜⩟
䛈㟠⣜̷ःАധ⮱Ѻ㒛ᄦࣺᏁϔ⢴Όᰶᒞ৺喑㟠⣜ 1 16 (14) 94

̷ᄦѺᰶःАധᬣ喑ϔ➖ϔ⢴ᰡສ喍Ꮌत 3Ƞ6Ƞ7喎ȡ
ᒀ㠜⩟䛈㟠⣜̷䗨ѺःАധͧ⏡ᬣ喑ϔ➖ϔ⢴䒰ጛ 2 16 (15) 89

喍Ꮌत 9喎喑䔆᭜ज㘪⩞⏡А㠜⩟䛈⮱⏣㼐ᕔጛ᝭㜡ȡ
ᒀ㟠⣜ͧ㥅⣜হநॖ⣜ᬣ喑ࣺᏁΌ㣤ᓄγ㞜ສ⮱ϔ 3 19 (16) 88
⢴喍Ꮌत 10~11喎ȡБϧ倅ڡ⮱᭜喑㘯㗗䛈Ό㘪হ 2-
ⷅΆ䚥Ά䚜䶧ݖࣺᏁ喍Ꮌत 12喎ȡិ 2-ⷅΆ䚥Ά䚜 4 16 (17) 90
ᢏ᜽ 2-ⷅ-2,2-ι⅌АΆ䚥Ά䚜ᬣ喑ϔ➖㣤ᓄγхᐯ
⮱ϔ⢴喍Ꮌत 13喎喑जВ᜽ߌౝౕϔ➖͚ᑂڒ䲋፥ 5 22 (18) 88
ᰶ⩕⮱⅌࣌ၽȡ
O
㶕 3 Ꮒ➖᠀ᆂ 6 I O 20 (19) 85
Table 3 Substrate scope
7 18 (20) 91

8 19 (21) 93
ࣺᏁ 喍ϔ➖喎
Ꮌत ē Ĕ
ᬣ䬡/h ϔ⢴/%
9 20 (22) 90

1 20 (1) 95

10 22 (23) 92
2 18 (2) 91

3 18 (3) 92
11 18 (24) 94

4 16 (4) 90

12 24 (25) 90
5 22 (5) 92

6 20 (6) 94 13 23 (26) 86

7 22 (7) 95
14 22 (27) 87

8 24 (8) 92

15 22 (28) 91
9 24 (9) 86

10 24 (10) 89 16 22 (29) 87

11 24 (11) 86
17 22 (30) 82

12 24 (12) 84
18 16 (31) 84
13 24 (13) 91

19 16 (32) 82

ₑใ喑ౕᰭхࣺᏁ᲎У̸喑䔅㔰ᄌγ CuI ϸᄩ喑
∕喟ࣺᏁ᲎Уͧ 1.0 mmol ĕȠ1.5 mmol ĔȠ3.0 mmol Zn
䨹ㆶיࡃ 2-ⷅΆ䚥Ά䚜̻̺ह㟠䚛⮱ Reformatsky
ㆶȠ0.2 mmol CuIȠ0.2 mmol CF 3CO 2HȠ2 mL V(Ά㙵)ńV(Ⅱ)=1ń
ࣺᏁ喑䔈̭ₒ᠀ᆂγࣺᏁ⮱ᮛ䔯ᕔ喑㐀᳉㻮㶕 4ȡ 1 ⮱⌤व⋟ͧ⏣ݯ喑ბ⍖ࣺᏁȡ