With fumaric acid, vinyl acetate and mixed higher alcohols as raw material , using first polymerization and then esterification, a new lubrication oil pour point depressant,the polymer of fumaric acid mixed higher alcohols ester- vinyl acetate (PPFVA).Through the single factor and orthogonal experiments,the suitable polymerization conditions for preparing PPFVA were obtained: n(fumaric acid):n(vinyl acetate)=1:0.75, w(BPO)=1.5%,polymerization time =3.5h , polymerization temperature =70℃,w(toluene)=55%；The suitable conditions for esterification ，n(fumaric acid- vinyl acetate polymer): n(mixed higher alcohols)=1:2, w(p-toluenesulfonic acid)=1.5%, w(toluene)=50%.The infrared analysis shows that the molecular functional group of the preparation products matches with the designing target products.SP of the lubrication oil was most lowered by 17℃ when the dosage of the pour point depressant was 1.16%(w) in the lubrication oil.