AlPO4-5 molecular sieves was prepared by hydrothermal reaction using triethylamine as template, aluminum isopropoxide, orthophosphate as the aluminum and phosphorus resource. Via chemical tailoring method with different concentrations of hydrobromic acid, AlPO4-5-AlBr3 catalysts were obtained. Several techniques such as high-resolution field-emission scanning electron microscopy (FESEM), X-ray diffraction (XRD) and N2 adsorption techniques were employed to investigate their morphology, structures as well as component. The characterization showed that AlPO4-5 was hexagonal crystal with microporous structur, after chemical tailored, AlPO4-5-AlBr3 still maintained the structure. The catalytic test was performed using 30 H2O2 as oxidant and ethyl acetate as solvent. It was revealed that the catalyst had good performances for some ketons, and could be reused several times.