Oxidized starch-aminothiazole Schiff-base (OSAT) was synthesized based on the reaction of aminothiazole (AT) and water soluble oxidized starch with high carbonyl content which was prepared by the oxidation of sodium hypochlorite. The synthesis conditions of OSAT were studied and the optimum conditions were as follows: nitrogen protection, water as solvent, adjusting the pH value of solution by acetic acid, pH = 5, T = 70 ℃, t = 16h. The substitution degrees of AT chould be adjusted by controlling the molar ratio of AT to carbonyl groups and the aldehyde groups utilization rate of 100% was achieved. The structure of OSAT was characterized by FT-IR, NMR and UV. The adsorption performance of OSAT to Cu2+ and Ag+ was also studied. The result showed that the adsorption capacity of OSAT (degree of substitution is 0.14) to Cu2+ and Ag+ was 0.82, 1.48 mmol/g, respectively.