Four benzamide compounds(HDDB、THBHB、HMBB、HBOMB) containing active structure of capsaicin were synthesized and their structures were confirmed by IR spectroscopy and 1HNMR. The bioassay results showed that all the four compounds possessed good antibacterial activity, with MIC value of HBOMB for Escherichia Coli and Staphylococcus aureus were 0.0625mg/mL and 0.1250mg/mL. And they were also studied as antifouling agents in antifouling paint, test panels immersed for 120 days were only covered with a few Balanus.