The glycomonomer 6-O-vinyladipoyl-D-glucopyranose (OVAG) was synthesized by lipase catalyzed transesterification of divinyladipate with D-glucopyranose. Poly(NIPAAm-co-OVAG) with narrow polydispersity (PDI) and thermosensitivity was prepared via Reversible Addition-Fragmentation Chain Transfer (RAFT) polymerization. The Poly(NIPAAm-co-OVAG) was characterized by 1H NMR, FTIR and gel permeation chromatography (GPC). Measurement by transmission electron microscopy (TEM) revealed that Poly(NIPAAm-co-OVAG) was able to self-assemble into nano micelle with well-defined structure and uniform size in aqueous solution. The characterization of UV-visible spectroscopy showed that the low critical solution temperature (LSCT) can be controlled by the molar ratio of monomers. When the molar ratio of NIPAAm and OVAG was 14:1, the LCST of Poly(NIPAAm-co-OVAG) was 36oC in aqueous solution, which can form nano micelle in the human body environment and has great potential in drug carrier.