Dendritic poly(amine-ester) with polyoxyethylene chain （PAE-PEO-A和PAE-SAA-PEO-A）is synthesized from a dendrimer with 8 primary amine as the terminal group[PAE(NH2)8] and poly(ethylene oxide) [PEO-A(454)] or sodium acrylate(SAA) and poly(ethylene oxide). Effects of reaction temperature, reaction time and ratio of reactants on the yield of products were discussed by orthogonal experiment. The structure of products was identified by FTIR. The surface tension of dendritic poly(amine-ester) with polyoxyethylene chain and their solubilization effects for benzoic acid and salicylic acid were determined. It was found that when reaction temperature reaction temperature was 65℃, reaction time was 96 h, n [PAE(NH2)8] : n [PEG-A(454)]=1:16, CH3OH as solvent, the yield was 88.30%. The critical micelle mass concentration of PAE-PEO-A solution was 0.0075 g/L. Its lowest surface tension was 43.8 mN/m. PAE-PEO-A has a solubilization of benzoic acid and salicylic acid. Solubilization capacity increased with increasing the number of surface functional groups and concentrations. It was found that when reaction temperature reaction temperature was 50℃, reaction time was 96h, n[PAE(NH2)8] : n (SAA) : n[PEO-A(454)] =1:12:8, CH3OH as solvent, the yield was 48.83%. It was found that PAE-SAA-PEO-A has good water solubility and surface activity. PAE-SAA-PEO-A has good solubilization of benzoic acid and salicylic acid, especially salicylic acid. PAE-SAA-PEO-A solution exhibits obviously solubilization effect for salicylic acid which is about 2.4 times that of PEG-400 at same concentration of 0.500g /L.