A new combustion catalyst-fullerene tyrosine lead salt was prepared with fullerenes, tyrosine and lead nitrate as raw materials. Synchronously, the structure of the target product was characterized by AAS、FT-IR、UV-VIS、MS、XPS. The thermal stability of fullerene tyrosine lead salt was studied by DTG and DTA, and the results indicated that the thermal stability of it was good. The interaction of RDX and fullerenes tyrosine lead salt was studied, showing that fullerenes tyrosine lead salt had a certain catalytic effect on the thermal decomposition of RDX，the value of lowering the activation energy of RDX is 13.28 kJ•mol-1.