Tetracycline HCl (TC•HCl) in an artificial wastewater was electrochemically degraded using IrO2-RuO2/Ti as anode and Ti as cathode. The impacts of initial TC concentrations, current density, pH value, electrolyte concentrations on the degradation effect of TC were investigated. The energy consumption and current efficiency were compared according to operating conditions to reveal the optimal condition for electrochemical degradation of TC HCl. Results showed that electro-catalytic oxidation could effectively remove TC in aqueous solutions. Higher current density, lower initial concentrations of TC•HCl and/or lower concentrations of Na2SO4 as electrolyte could enhance the removal rate of TC•HCl. During 0-90 min of the reaction, pH had no effect on the removal rate. After 90 min, acidic and alkaline conditions both partly inhibited the degradation of TC HCl, for example, the removal rates at pH 3, 7 and 12 were 92 %, 100 % and 72 % after 300 min respectively. Degradation procedure was in accordance with the first-order kinetic model. With the analysis of the removal rate, energy consumption and current efficiency under various operating conditions, the optimal condition constitute the initial TC•HCl concentration of 300 mg/L, the current density of 10 mA•cm-2, the Na2SO4 concentration of 0.05 mol•L-1 and the pH value of 7 with a removal rate of TC•HCl 94 % after 180 min. The present study provides so far the primary data for wastewater management against TC HCl.