2,4-bis(n-octylthiomethyl)-6-methylphenol was synthesized from o-cresol, o-octanethiol and paraformaldehyde using piperidine as catalyst and N,N-dimethylformamide as solvent under nitrogen protection. The effect of various reaction parameters, including material ratio,the amount of catalyst,reaction temperature and time, was investigated in detail. When the molar ratio n(o-cresol): n(o-octanethiol): n(paraformaldehyde) = 1:2:4, the amount of piperidine was 9.8% of o-cresol, at 110℃ for 8 hours ，the target compound 2,4-bis(n-octylthiomethyl)-6-methylphenol had a higher yield of 94.5%. The product was verified by means of IR and 1HNMR.