H4SiW12O40/SiO2 exhibited excellent catalytic for synthesis of 4-Phenyl-6-Methyl-5-Ethoxycarbonyl -3,4-Dihydro -pyrimidin-2(H)-one via one-pot Biginelli reaction from benzaldehyde, ethyl acetoacetate, urea and anhydrous ehanol as soivent.The effects of reaction on the yield of the product were investigated and the optimum conditions were determined as follows: under the condition of fixed benzaldehyde consumption is 0.04mol n(benzaldehyde):n(ethylacetoacetate):n(urea)= 1:1.5:1.5,the quantity of catalyst was 2.0% quantity of the feed stock , reaction temperature was 90℃, and reaction time was 1.0h .The yield of the product was up to 71.7%.The 3,4-Dihydropyrimidin-2(H)-one were characterized by melting point measure ments,IR 1HNMR and MS spectroscopy.