To explore a new route for the synthesis of efinaconazole, intermediate 4-[(R)-2-hydroxypropiony]morpholine（Ⅱ）was prepared from starting materials R-methyl lactate by amination with morpholine, (2R)-2’,4’-difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2- lyoxy)propiophenone（Ⅳ） was synthesized by reacting with 2,4-difluorophenyl magnesium bromide after hydroxy group was protected. Precursor (2R,3R) -2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)- 2,3-butanediol（Ⅶ） was obtained via Corey-Chaykovsky epoxidation, trizole alkylation and deprotection in one pot reation. After reacting with methanesulfonyl chloride , epoxidation and subsequent alkylation with 4-methylenepiperidine, the product efinaconazole（Ⅰ） was acquired. The total yield of efinaconazole（Ⅰ） was increased from 17% to 24% with purity of more than 99% determined by HPLC. The stucture of product was characterized by means of 1HNMR, ESI-MS and polarimetry.