Abstract: Thirteen microporous resins with different polarity were evaluated for the adsorption properties of the total caffeoylquinic acid ester(TCaf) from Erigeron multiradiatus. Macroporous resin NKA-2 with strong polarity displayed the best adsorption capacity among the tested resins. The static adsorption and dynamic adsorption test of NKA-2 for TCaf from Erigeron multiradiatus were investigated.The results show that the optimal purification parameters were sample concentration of 300 g/L,the loaded amount of 6 mL/g,and loaded flow rate of 2 BV/h. By analyzing the TCaf from Erigeron multiradiatus washed out from the resin,it was shown that the desorption effect of 60% ethanol of 8 BV was the best.The purity of TCaf increased to 58.06% after the purification,and the yield was 94.78%.NKA-2 is an ideal resin with the best enrichment efficiency for the TCaf of Erigeron multiradiatus.