Twelve compounds 3,3-bis(ethylthio) acrylophenone and 2-(bis(ethylthio)methylene)-3-oxobutanoate with indole reaction were synthesized by I2 loaded montmorillonite.The stucture of product was characterized by means of infrared spectroscopy(FTIR),nuclearmagnetic resonance spectrum(NMR).The effects of reaction temperature, the amount of catalyst, equivalent ratio of starting materials and reaction time on the reaction were considered.The experiments showed that the optimized reaction conditions were:reaction temperature 80℃, the molar ratio of catalyst MMT/I2 and 3,3-bis(ethylthio) acrylophenone was 0.1:1.0, the molar ratio of 3,3-bis(ethylthio) acrylophenone and indole was 1.0:1.0 and reaction time 1h.The yield of 3-indolyl-3-ethylthio acrylophenone was 89% and still reaches 86% after catalyst recycling for four time.