The biological aviation kerosene was produced by one-step hydro treatment over Pt/SAPO-11-mp with palm oil as raw material in the high-pressure micro fixed bed. Based on single factor experiments, Box-Behnken central composite design by response surface methodology was applied to study the effect of the process conditions about temperature, pressure, space velocity, hydrogen oil ratio (hydrogen volume/ palm oil volume) on the percentage of C8-C16 hydrocarbons. At last, the response surface optimization experimental results show that the temperature of 382.2℃, pressure of 3.9MPa, space velocity of 1.2h-1, hydrogen oil ratio of 911.0 are the best experimental reaction conditions. Under these conditions, the verification experiment was carried out 3 times，the selectivity of C8-C16 hydrocarbons and C8-C16 iso-alkanes respectively are proved 44.9% and 27.9%