By solvent thermal method, Fe-based MOFs (MIL-53) with terephthalic acid (H2BDC) as ligand was prepared. When chrome tanning agent was used as main tanning agent and weight at 3% tare (as for Cr2O3 is 0.75%), ultrasonic MIL-53-Fe was used as retanning agent and weight as 2% tare, the shrinkage temperature reached 101.8 ℃, reducing the dosage of chrome tanning agent 40%, tanned leather thickening rate reached 18.1%, the tensile strength reached 29.56 MPa, the elongation at break was 89.77%, the tannage leather performed a good water resistance and high absorption rate of chrome tanning agent. When the MIL-53-Fe have tanned leather alone, the shrinkage temperature reached 72.5 ℃, compared with the acid skin, there is a certain improvement, showing certain tanning. Experiments show that MIL-53-Fe can used with chromium tanning agent, improving the performance of washed leather,the rest of MIL-53-Fe can adsorb the organic waste in wastewater, and reduce the content of harmful substances in wastewater, which owns a good meaning in lesser chromium tanning and reducing the polluting of wastewater.