Based on the current research situation that Cu-based catalysts are inclined to inactivate in diethanolamine dehydrogenation process because of oxidizing and agglomerating. Therefore, the dehydrogenation mechanism of diethanolamine was introduced. Moreover, the influences of supporters, different additives and microstructures on the performances of Cu-based catalysts were summarized. In the future, the development of diethanolamine dehydrogenation should seek a highly efficient catalyst, also should pay attention to continuous manufacturing. The development of continuous manufacturing at home and abroad is briefly introduced. Finally, the trend modification of Cu-based catalysts and realizing the continuous manufacturing of diethanolamine dehydrogenation were proposed.