A series of supported bimetallic RuPd catalysts were prepared by wet impregnation method using Al2O3, PdCl2 and RuCl3 as raw materials under the conditions of controlling the immobilization sequence, prepa-ration process and calcination temperature. And then these catalysts were used for the selective hydro-genation of dimethyl terephthalate (DMT) to dimethyl cyclohexane-1,4-dicarboxylate (DMCD). In which, the total loading of Ru and Pd was 0.3% (based on the total mass of the catalyst, the same below), and m(Ru) : m(Pd)= 1:1. The results showed that the catalyst had the best catalytic performance which was prepared using impregnation sequence of first Pd then Ru (Ru-Pd type) and impregna-tion-drying-impregnation-drying-calcination (IEIEC) preparation process and then calcinated at 450℃. Under 6.0 MPa and 180℃, the DMT conversion, DMCD selectivity and DMCD yield reached 89.6%, 96.0%, and 85.9%, respectively, which could be ascribed to the inhibition of the formation of large particle size, the smaller particle size and distribution, the higher specific surface area and total pore volume, the higher molar proportion of surficial Pd, and the lower surficial Ru/Pd molar ratio.