To study the transfer behavior of non-phenyl ester plasticizers in cigarette mainstream smoke, add 12 non-phenyl ester plasticizers to cigarette cut tobacco, and use Cambridge filters to capture mainstream cigarette smoke, Cambridge after the filter and the cigarette butts were extracted by dichloromethane, the transfer ratio of the non-phenyl ester plasticizer in the mainstream smoke and the rejection ratioof cigarette butt were determined by GC/MS/SIM. The results show: The transfer ratio of 12 non-phenyl ester plasticizers in mainstream smoke was 7.86 % ~ 15.11%; The retention ratio of 12 non-phenyl ester plasticizers in cigarette butts was 18.65 % ~ 36.54 %; The rejection ratio of non-phenyl ester plasticizers in cigarette butts is significantly higher than the transfer ratio of non-phenyl ester plasticizers in mainstream smoke.The transfer ratio of diethyl adipate in mainstream smoke is the lowest, while the rejectionratio of cigarette butts is the highest.