Herein by immobilizing Ru and synthesizing HTc-Al2O3 simultaneously, Ru-HTc-Al2O3 was prepared for dimethyl terephthalate (DMT) to dimethyl cyclohexane-1,4-dicarboxylate (DMCD). For comparison, Ru/HTc-Al2O3 and Ru/Al2O3 were obtained based on the wet impregnation. The characterization results showed that, compared with Ru/HTc-Al2O3 and Ru/Al2O3, Ru-HTc-Al2O3 with larger specific surface area inhibits formation of large Ru particles as well as Ru leaching, behaves the concentrated distribution toward smaller size; and has more surface acid sites especially for the moderate ones. By varing CRR、temperature and pressure as well as the recycling test, one catalytic sequence presents: Ru-HTc-Al2O3 > Ru/HTc-Al2O3> Ru/Al2O3；under 100 g/mol, 180 ℃ and 8 MPa, Ru-HTc-Al2O3 behaves the optimal: 98.2% for DMT conversion, 96.9% for DMCD selectivity.