The whitening effects of pine salt, plum salt and bamboo salt were evaluated in vitro, and their inhibitory effects on tyrosinase monophenolase and diphenolase activity were studied in vitro. The B16 melanoma cell model was used to explore effects of salts on intracellular tyrosinase activity, cell proliferation and migration and arbutin was used as a positive control. The results showed that plant salts are rich in elemental composition and the aqueous solutions are alkaline, and pine salt, bamboo salt and plum salt showed extremely significant concentration-dependent inhibition of tyrosinase activity (p<0.01). When the concentration of the three plant saline solution was 50.0 g/L, the inhibition rates of tyrosinase monophenolase were 94.8%, 94.8%, and 48.2%, respectively, and the inhibition rates of diphenolase were higher than 92.0%. When acting on B16 cells, compared with the original salt, the inhibitory effect of 5.0 g/L plants salt on the growth of B16 cells was not obvious, but it inhibited the lateral migration. The inhibitory effect of plant salt on the intracellular tyrosinase activity of B16 cells was better than that of arbutin, and the intracellular tyrosinase of 7.5 g/L plum salt group is only 8.76%, and the inhibition effect is better than that of pine salt and bamboo salt. The above results indicate that plant salt can inhibit the activity of tyrosinase and has no additional toxicity to B16 cells, showing its potential as an inorganic tyrosinase inhibitor, and has a good potential application value in human whitening.