Enzyme mimics of nanomaterials have been used in Fenton reactions as heterogeneous reagents to degrade organic pollutants in water due to their advantages such as high stability, low cost, and easy preparation. This article briefly summarizes the mechanism of catalytic degradation of organic pollutants by nano-mimetic enzymes based on Fenton reaction, and focuses on the recent degradation of dyes, phenols, antibiotics, and pesticides in drinking water by mimic enzymes based on Fenton reaction. The latest research progress of organic pollutants, and the future challenges and application prospects of this method are prospected.