Sugarcane bagasse was used as raw material to prepare monocarboxylic sugarcane bagasse cellulose by HNO3/H3PO4-NaNO2 mixture system; then, in the presence of crosslinking agent cystamine bisacrylamide (CBA), redox, pH and thermal-responsive nanogels were prepared via the in-situ free radical copolymerization of methacrylated monocarboxylic sugarcane bagasse cellulose (MAMC-SBC) and N-isopropylacrylamide (NIPAM) in aqueous phase. The results obtained from FT-IR, 1H NMR, SEM and high precision particle size analyzer show that the nanogels were highly uniform with an average particle size were 183± 2 nm. Adriamycin hydrochloride (DOX) was effectively loaded into the nanogels as a model drug with a drug loading efficiency of up to 82.7 %. The results reveal that it can be controlled the release of drugs precisely by reducing agents, pH and temperature and the synergistic effects.