With solid heteropolyacid as the component, the dual-functional catalyst for alkane isomerization exhibits excellent catalytic activity, and has the advantages of mild catalytic reaction conditions, no corrosion of equipment, and no environmental pollution. It has broad application prospects and has become a research hotspot in the field of alkane isomerization catalysts. This article reviews the research progress of heteropolyacids used in the isomerization of light alkanes, and discusses in detail the influence of various supports, metal active components and mixing methods of supported heteropolyacid on isomerization performance. The structure activity relationship between heteropolyacid-based catalyst and isomerization performance was analyzed. In addition, combined with the main problems of current catalysts, the future research direction of heteropoly acid-based isomerization catalysts was point out.