The paper shows a new terbium (Ⅲ) complex OSNP@Tb3+ based on oxidized starch nanoparticles (OSNP), which can emit strong green fluorescence at 320 nm excitation wavelength. The furazolidone will especially behave the highest sensitivity and selectivity during detecting different antibiotics by using OSNP@Tb3+ as fluorescence probe. The luminescence intensity of OSNP@Tb3+ aqueous dispersion gradually decreases with the increase of furazolidone concentration. The luminescence can almost be quenched completely (quenching efficiency > 90%) at the concentration of 2.3 × 10-4 mol/L. OSNP@Tb3+ aqueous dispersion presents high quenching constant (Ksv = 1.919 × 104 (mol/L)-1, good linear relationship (R2 = 0.992) and low detection limit (1.67 × 10-6 mol/L) when it was used for detecting furazolidone.