The free radical solution polymerization method was used to synthesize acrylamide(AM)/itaconic acid(IA)copolymer IAPAM,its structure was characterized by FTIR,1HNMR,elemental analysis and GPC,and having evaluated the ability of the reducing viscosity of resisting monovalent and divalent cations and resisting redox substances. The experiment determined that the viscosity average molecular weight of IAPAM was as high as 1.716×107. The evaluation results of IAPAM salt resistance performance show that compared with Partially hydrolyzed polyacrylamide(HPAM),IAPAM has better resistance to monovalent and divalent cations to reduce viscosity. When the Na+/Ca2+ concentration is 30000mg/L and 500mg/L,the viscosity of IAPAM is respectively 196.8mPa·s and 161.56 mPa·s,the viscosity reduction rates were 22.44% and 35.51% respectively. The results of anti-oxidation and reduction substance evaluation experiments show that IAPAM has good resistance to degradation of Fe2+ and S2-. When the concentration of Fe2+/S2- is 10mg/L the viscosity reduction rate is 23.67% and 0.56%, respectively. The structure of the monomer IA is related. However, the complex stabilization effect of IAPAM on Fe2+ takes a certain amount of time. When the stable state of complexation is not reached,the oxidative degradation of the polymer by Fe2+ can still proceed.