Abstract:As an effective method of constructing carbon-carbon bonds, the Suzuki coupling reaction of palladium catalysis has been widely used in natural products, total pharmaceutical synthesis and organic synthesis industries. The currently widely used palladium-containing homogeneous catalysts have high reaction activity, but expensive palladium metal salts or complexes are not easy to be recycled, and traces remain in the target product or waste liquid, causing heavy metal pollution of the target product and environmental pollution, which greatly increases the cost of the reaction and reduces the safety of the product. Therefore, it is expected that a heterogeneous catalyst that is easy to be recycled and low in palladium leaching can be used to achieve high-efficiency and green catalysis of the reaction.The nitrogen heterocyclic carbene palladium complex (NHC-Pd) has the advantages of high reactivity and good stability in catalyzing the Suzuki coupling reaction, and is often used as the catalytic center of heterogeneous catalysts. Starting from the support materials of heterogeneous catalysts such as polymer materials, porous silicon materials, carbon-based materials, metal-organic frameworks and magnetic nanoparticles, this paper reviews the latest research progress of NHC-PD in heterogeneous catalytic Suzuki coupling reaction in recent year, which has guiding significance for the development of this research direction in the future.