AgNPs@graphene composite material was prepared by a one-step method by using natural flake graphite, silver nitrate, sodium citrate, and N-methylpyrrolidone as raw materials. Then, thermoplastic polyurethane (TPU) is coated on the surface of the composite material to obtain a flexible stress sensor based on AgNPs@graphene. AgNPs@graphene composite material is characterized by XRD, TEM, and SEM. The electrical and mechanical properties of the flexible stress sensor are collected by a tensile tester and a data acquisition instrument. The result shows that the sensitivity of AgNPs@graphene flexible stress sensor can reach 299, which is much higher than that of pure graphene. At the same time, it has excellent vibration response and cycle stability, and its performance is still stable after 1000 cycles. It can effectively identify tensile strain and compressive strain, and track and monitor the movement of human body surface muscles in real time, which is a potential artificial intelligence skin.