Nicofluprole is a novel fluorinated phenylpyrazole nicotinamide insecticide successfully developed and marketed by Bayer. The mechanism of action has not been reported yet. The synthetic method for Nicofluprole was explored, and its insecticidal activities were tested. Nicofluprole was prepared with aniline and 5-bromo-2-chloronicotinic acid as starting materials, and its structure was confirmed by 1H NMR, 13C NMR和MS compared with the literature hydrogen spectrum data of Nicofluprole. This synthetic route has a higher total yield and lower cost. Nicofluprole has higher insecticidal activity against the lepidoptera pests (Plutella xylostella and armyworm), the homoptera pest (Myzus persicae) and the Acarina pest (Tetranychus cinnabarinus). The lethal rate of Nicofluprole can reach 100% against Plutella xylostella at 2.5 mg/L, 100% against armyworm at a concentration of 10 mg/L and 71% against Tetranychus cinnabarinus at 5 mg/L. Nicofluprole also had a good control effect on Myzus persicae at a concentration of 10 mg/L.