PPCPs are a new type of organic pollutants. Compared with common pollutants, PPCPs have a low concentration in the aquatic environment but have a complex chemical structure, various sorts, enormous properties, and are toxic. The conventional processing technology is difficult to remove PPCPs completely. The solid-phase catalyst of heterogeneous catalytic ozonation technology can be recycled and reused and has less secondary pollution. At present, the research of this treatment technology in the field of PPCPs has been extensive. The article describes the surface reaction mechanism, free radical reaction mechanism, and synergistic reaction mechanism that the heterogeneous catalytic ozonation technology often follows to degrade PPCPs. Meanwhile, it further explained the four ways in the free radical reaction mechanism. The article briefly introduces the effects of catalysts and other factors on the degradation of PPCPs, summarizes the application progress of heterogeneous catalytic ozonation in the treatment of PPCPs, and puts forward the problems existing in the current heterogeneous catalytic ozonation technology. Ultimately, the article prospects the future research direction and application prospects of heterogeneous catalytic ozonation technology.