Nano micelles are good carriers for anticancer drug - doxorubicin (DOX). It has received great attention in the application of controlled release of hydrophobic drug. In this study, we used three times of Activators Regenerated by Electron Transfer Atom Transfer Radical Polymerization (ARGET ATRP) to prepare a thermally responsive amphiphilic triblock polymer: poly (perfluoroacyl fluoride polyether hydroxyethyl methacrylate9)-b-poly(dimethyl methacrylate) Acrylamide)-b-poly(polyethylene glycol methacrylate360) (P(PFPHM9-b-DMAA-b-PEGMA360)). The self-assembly ability, lower critical solution temperature (LCST), biological toxicity, DOX encapsulation rate, simulated human temperature (37 ℃) and cancerous tissue temperature (42 ℃) were investigated to test the drug release ability of nano micelles. The results showed that the critical micelle concentration of P(PFPHM9-b-DMAA-b-PEGMA360) was 1.0 μg/L。, the drug loading capacity of P(PFPHM9-b-DMAA-b-PEGMA360) micelles was 20.6 %, the encapsulation rate was 86.7 %, LCST was 39 ℃, and the drug release rate was 95.9 % and 33.5 % at 42 ℃ and 37 ℃, respectively. These results indicate that P(PFPHM9-b-DMAA-b-PEGMA360) is temperature sensitive and has great potential as a drug carrier for DOX.