In order to solve the problem of poor fatigue resistance of spiropyran organic photochromic material in practical application, the spiropyran photochromic material is used as the core material and polystyrene as the shell material to prepare spiropyran photochromic microcapsule by solvent evaporation method. And the photochromic microcapsules are printed on the fabric to obtain the photochromic fabric. The results show that the microcapsules are completely coated, the surface is smooth, the average particle size measured by the particle size analyzer reaches 700 nm, and the particle size distribution is relatively dispersed. The photochromic microcapsules have good discoloration performance. It can change from white to purple in 20 s under ultraviolet light irradiation, and can return to the initial state in 8 minutes in a dark environment. The color difference ΔECMC of the printed fabrics with photochromic microcapsules before and after discoloration reaches 36.10, and it still has good discoloration sensitivity after 20 cycles of UV-visible light irradiation. Therefore, the obtained photochromic microcapsules have good application potential in fields such as smart textile materials.