葡萄糖响应型丙烯基氧化石墨烯微凝胶Pickering乳液的制备及性能
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西北大学化工学院

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Preparation and properties of glucose-responsive GOM microgel Pickering emulsion
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1.School of Chemical Engineering, Northwestern University, Xi'2.'3.an, Shaanxi,China;4.School of Chemical Engineering,Northwestern University,Xi'5.an;6.School of Chemical Engineering, Northwestern University, Xi'an, Shaanxi,China;7.an , Shaanxi,China

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    摘要:

    提出以具有葡萄糖敏感的GOM/Poly(AAPBA-DMAA-co-AAm)微凝胶为Pickering 乳液中的乳化剂,为使用具有特定响应行为的功能性微凝胶提供了更广泛的应用。采用傅里叶红外光谱分析仪(FT-IR)、扫描电镜-X射线能谱(SEM-EDS)对微凝胶的形貌结构及元素组成进行表征。通过调控微凝胶中丙烯基氧化石墨烯(GOM)的含量和微凝胶在水相中的含量,制得了粒径分布均匀、分散性良好的具有葡萄糖敏感的O/W型稳定Pickering乳液。以胰岛素为模型负载药物,体外模拟释药表明:当葡萄糖的浓度为6 mM时,胰岛素的累积释放率可达到44.69%,当葡萄糖的浓度增加至40 mM时,胰岛素的累积释放率可达到94.21%。

    Abstract:

    GOM/Poly(AAPBA-DMAA-co-AAm) microgels with glucose-sensitive properties are proposed as emulsifiers in Pickering emulsions, providing a wider application for the use of functionalized microgels with specific response behaviors. The morphological structure and elemental composition of the microgels were characterized by Fourier infrared spectroscopy (FT-IR) and scanning electron microscopy-X-ray energy spectroscopy (SEM-EDS). By regulating the content of propylene-based graphene oxide (GOM) in microgels and the content of microgels in the aqueous phase, O/W-type stable Pickering emulsions with uniform particle size distribution and good dispersion were fabricated with glucose sensitivity. The in vitro simulated drug release using insulin as a model loaded drug showed that the cumulative release rate of insulin could reach 44.69% when the concentration of glucose was 6 mM and 94.21% when the concentration of glucose was increased to 40 mM.

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刘应林,秦艳琼,刘巍征,袁英慧,郝红.葡萄糖响应型丙烯基氧化石墨烯微凝胶Pickering乳液的制备及性能[J].精细化工,2023,40(9):

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  • 收稿日期:2022-11-16
  • 最后修改日期:2023-02-04
  • 录用日期:2023-02-17
  • 在线发布日期: 2023-08-17
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